Pathelen Hybrid Wound Treatment

The burden on the health system

caused by chronic wounds

The most common chronic wounds include venous leg ulcers (Ulcera cruris),

diabetic foot syndrome and pressure sores. In addition to the considerable costs of

the respective standard treatment, these wounds are usually infected with germs

that require the additional use of antibiotics.

PATHELEN  Hybrid is a combination of

active ingredients consisting of various

fumed silica which efficiently eliminate

biofilms and multi-resistant germs by

physically removing them out of the




PATHELEN  Hybrid is the first one-step solution for the efficient removal of biofilm.

PATHELEN  Hybrid is a wound therapy containing both hydrophilic and hydrophobic

fumed silica. The extra large surface structure of the fumed silica (1 bottle of Pathelen

Hybrid contains 2g with a surface area of approx. 600 m ) generates an extra high

capillary action for the adsorption of biofilm, wound exudate, toxins and pathogenic

germs. This ensures fast and efficient physical wound cleaning.

PATHELEN  Hybrid is a medical device class 1 registered with SWISSMEDIC and US

FDA and approved in the EU, Turkey, Canada, EFTA and USA.


Antibiotics in Wound Care

Since 2011, western countries like Germany have been advocating a systematic

reduction in the use of antibiotics.1 In Germany a S3 guideline on the rational use

of antibiotics (antibiotic stewardship) has been in place since December 2013.2

In the treatment of chronic wounds, the local application of antibiotics is already no

longer standard of care and thus obsolete. Local application of antibiotics can lead

to the development of polyvalent contact allergies, the formation of resistance and

thus a decisive disturbance of wound healing.3

Systemic antibiotic therapy is only indicated if MRSA is detected and a wound

infection is present. Reserve antibiotics are used for this purpose.


Biofilm in chronic wounds

Biofilm is a complex microbial community of bacteria and fungi that forms a viscous

matrix of sugar and proteins to protect against external threats. 60 to 90% of all

chronic wounds have a biofilm.

Biofilms stimulate a chronic inflammatory reaction as the body’s immune response

and thereby impede wound healing. The resulting increase in wound exudation helps

the biofilm to improve its nutritional situation. The biofilm is therefore better able to

establish itself in the wound.